WebNov 19, 2013 · The Klotho gene was identified as an ‘aging suppressor' in mice. Overexpression of the Klotho gene extends lifespan and defective Klotho results in rapid aging and early death. Both the membrane and secreted forms of Klotho have biological activity that include regulatory effects on general metabolism and a more specific effect … WebMar 30, 2015 · Search worldwide, life-sciences literature Search. Advanced Search

Biological Role of Anti-aging Protein Klotho. - Abstract - Europe …

WebKlotho plays a major role in kidney disease as much of the Klotho protein circulating in the blood is produced in the kidneys. ... Aging is a complex biological process regulated by multiple intrinsic and extrinsic factors such as genetics, epigenetics, environment, lifestyle, and immune response. Aging is often defined as an age-related ... WebIntroduction. Klotho, the gene encoding the antiaging protein called klotho, was discovered in 1997 when mice developed multiple organ failure and shortened life span … list of accounting practices

Melissa Rudy - PhD Candidate - Baylor College of …

WebIntroduction. Klotho, the gene encoding the antiaging protein called klotho, was discovered in 1997 when mice developed multiple organ failure and shortened life span resembling human premature aging after this gene was serendipitously silenced. 1 The klotho-deficient phenotype can be rescued by overexpressing klotho via genetic … WebKLOTHO ESSENTIALS. In mice, brain expression of KL protein begins in utero [], increases dramatically after birth and into adulthood [], and is downregulated with advancing age [].As with the human protein [], mouse KL is detected as three distinct forms [] ().Transmembrane KL is a 130kDa, glycosylated, type 1, single pass protein with a very … WebFeb 1, 2024 · The α-Klotho gene is located on human chromosome 13 and contains five exons [1, 2] and encodes a single-pass type I transmembrane protein with three domains: a short intracellular domain (~60 amino acids), a transmembrane domain, and a large extracellular domain (~950 amino acids).As an anti-aging protein, α-Klotho is widely … list of accounting courses