Cisplatin in animal bedding

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August undefined, 2024

WebMar 1, 2005 · Cisplatin is an important chemotherapeutic agent that is noted for its activity against testicular germ cell cancer. As a heavy metal coordination compound, cisplatin produces cross-links, including the DNA cross-links that are presumably responsible for its antineoplastic effect ( 20). WebOct 7, 2024 · The severity of mucosal damage along the gastrointestinal tract is dose-dependent [72]. Mucosal damage with inflammation, digestive dysfunction, disruption of …

Chemopreventive Effects of Dietary Isothiocyanates in Animal …

WebSep 13, 2024 · The mouse cisplatin administration protocol (Roy et al., 2013) involves multiple cisplatin cycles spread over time (as is the case for patients), and it reliably elicits hearing loss but leads to less than 10% animal mortality. Compared to this protocol, we halved the duration of the last chemotherapy cycle in an effort to further reduce animal ... WebOct 7, 2024 · Cisplatin causes acute and chronic effects in the gastrointestinal tract. A single injection of cisplatin causes pica, a rodent-specific behavior of nausea, which reflects as a progressive reduction in food intake, increase in non-nutritive material intake (for instance bedding) and decreased gastric motility . how to dowload optifine 1.18.2

Cisplatin Mouse Models: Treatment, Toxicity and Translatability

WebMay 1, 2005 · The antineoplastic drug cisplatin, whose use in humans is limited by kidney toxicity, also causes typical histological changes and a decline in renal function in larval zebrafish. A specific inhibitor of Omi/HtrA2, a serine protease implicated in cisplatin-induced apoptosis, prevented renal failure and increased survival. WebMar 15, 2024 · Cisplatin, a heavy metal complex, is one of the most effective chemotherapeutic agents used for the treatment of a wide variety of malignancies (Zhang and Lippard, 2003). However, dose-dependent and cumulative nephrotoxicity is a major side effect of cisplatin, leading to reduction in dosage or ceasing its use. WebCisplatin is a platinum -based chemotherapy drug, an antineoplastic ag ent . It is cytotoxic, nephrotoxic and neurotoxic. Cisplati n may be harmful if inhaled, ingested, or … how to dowload google earth

Impact of Cisplatin Dosing Regimens on Mammary Tumor Growth …

Cisplatin Mouse Models: Treatment, Toxicity and …

WebDec 5, 2007 · Beads are 3 mm in diameter and contain ≈1.6 mg of cisplatin/bead [c]. Beads are sterilized by means of gamma irradiation and stored in the dark at room temperature … WebCisplatin, a single dose of 3.5 mg/kg, i.p., was injected on day 1 which served as standard drug. Every third day animals were weighed to assess the tumor growth. The animals were monitored daily for 45 days and mortality was recorded to calculate the MST (mean survival time). The percentage increase in life span (ILS) was calculated by the ... how to down a docker containerWebMay 15, 2024 · The doses of cisplatin were applied based initially on those described in mouse models 15, 16, 17, in which the standard used is 10-13 mg of cisplatin per kg of animal (mg/kg). However, the zebrafish showed to be more resistant to cisplatin than the mouse (data not shown), and the final dose was increased. leasowes community college

"WebOct 7, 2024 · Cisplatin retention in the tissues can be evaluated also by detecting cisplatin-DNA adducts, a method usually used in the nervous system (see section neurotoxicity). " - Cisplatin in animal bedding

Cisplatin in animal bedding

Assessment of low-dose cisplatin as a model of nausea …

WebJan 12, 2024 · To evaluate whether cilastatin influences the antitumor effects of cisplatin in human cancer cells, SCID mice were injected with A549 human lung adenocarcinoma … Webwoodchip bedding under a 12 : 12 h light : dark cycle and room temperature 22–24ºC. Rats were acclimatized to the ... In the Cisplatin-treated group, animals were given a single intraperitoneal dose of Cisplatin (10 mg/kg body weight), used previously to induce testicular toxicity in various animal species (9, 41); Following diethyl ether ...

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WebFresh micro-isolator caging will be used for the animals at the time of administration. Danger Sign . must be posted on the door of the room in which the animals will be … WebApr 22, 2024 · The results were encouraging. In the presence of panobinostat, ACTL6A could no longer promote cisplatin resistance. Panobinostat resensitized ACTL6A-overexpressing cells to cisplatin, …

WebJan 12, 2024 · Administration of cilastatin suppressed cisplatin-induced kidney injury. (A) BALB/cA mice were administered cisplatin i.p. at a dose of 3 mg/kg or 6 mg/kg on days 0, 3 and 6.Mice that received 6 ... WebIt is not at all surprising that cisplatin retards tumor growth in our animal model. Cisplatin is an alkylating agent that is cell cycle nonspecific, and has long been used in the management of breast cancer . Relative to a single bolus at time 0, multidosing regimens show some advantage (Figure 2). One might infer that, at least in the case of ...

Web2. Animal cages and bedding are considered hazardous for a minimum of 3 days (36 hours) after an injection. The first cage change after each drug administration is to be done no sooner than 3 days after the administration. 3. The bedding is considered contaminated and requires special handling. The first bedding change WebOct 5, 2014 · Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinoma …

WebJul 12, 2024 · Cisplatin is used to treat a number of different tumors in dogs. The most common ones include osteosarcoma, squamous cell carcinoma, bladder tumors, ovarian …

WebAccordingly, in the present studies, we sought to determine (i) the effects of cisplatin treatment on thermal and mechanical thresholds, (ii) the effects of this treatment on DRG … leasowe railway stationWebcisplatin doses of 18 and 22 mg/kg, the half-life of cefepime was signiÞcantly prolonged of 18 mg/kg cisplatin. Serum levels of cefepime after the pretreatment with … leasowe primary school facebookWebSunseed Natural Corn - for Pet Birds and Small Animals Corn Cob bedding USA. Sponsored. $24.99. Free shipping. Sunseed Natural Corn Cob Bedding & Litter for Pet Birds and Small Animals â€“... $15.72. Free shipping. Sunseed Natural Corn Cob Bedding & Litter for Pet Birds and Small Animals â€“... how to dowload a video from vimeoWebApr 17, 2024 · Animals. Animal preparation All protocols were approved by the Institutional Animal Care and Use Committee and conducted accordingly to the Guide for the Care and Use of Laboratory Animals … leasowe primary school ch46 1ruWebAug 9, 2010 · Abstract and Figures We developed a dextran-magnetite conjugated cisplatin (DM-Cis) complex for use in thermal ablation and as a chemotherapeutic drug. To produce DM-Cis we reacted Cis with 1 mL... leasowe primary school logoWebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms … leasowe shopsWebApr 8, 2024 · First, we did not include additional animal groups, e.g., normal mice, MNU and INS-GAS mice that should be treated with PEITC or cisplatin alone and combination of PEITC plus cisplatin to explore the possibilities that PEITC may have differential effects on gastric cancer cells compared to normal gastric epithelial cells and that there is ... leasowes care centre smethwick