TīmeklisFBXL2 is palmitoylated in a prenylation-dependent manner on cysteines 417 and 419 juxtaposed to the CaaX motif. Palmitoylation/depalmitoylation regulates its subcellular trafficking for substrate engagement and degradation. To control its subcellular distribution, lipid-modified FBXL2 interacts with PDE6δ. Tīmeklis2024. gada 15. jūl. · Increasing Fbxl2 levels with nebivolol (102) (Fig. 14) in combination with osimertinib or a Grp94 inhibitor (ganetespib) to target the FBXL2-Grp94-EGFR axis and thus destabilize EGFR is a possible therapeutic strategy to overcome resistance to third-generation EGFR-TKIs . AKR1B1 inhibitors
FBXL2 counteracts Grp94 to destabilize EGFR and inhibit …
TīmeklisDownload scientific diagram FBXL2 interacts with the kinase domain of EGFR and its membrane-targeting function is essential for the destabilization of EGFR protein a A schematic representation ... TīmekliseGFR Calculator. Glomerular filtration rate (GFR) is the best overall index of kidney function. Normal GFR varies according to age, sex, and body size, and declines with age. The National Kidney Foundation recommends using the CKD-EPI Creatinine Equation (2024) to estimate GFR. More information regarding this recommendation … briggs and stratton pressure washer o rings
Discovery of a novel EGFR ligand DPBA that degrades EGFR and
TīmeklisSee all FBXL2 primary antibodies Description Goat polyclonal to FBXL2 Host species Goat Tested applications Suitable for: IHC-P, WB more details Species reactivity … TīmeklisQ9UKC9 FBXL2_HUMAN. General info Cross-references Sequences Orthologs Predictions Palmitoyl-proteomes References. Palmitoyl-proteomes. 0/22 article for human 0 ortholog. Palmitoyl-proteome experiments. Validation experiments. 0 experiment 0 ortholog. Curated sites & Enzymes. TīmeklisK10268 FBXL2_20; F-box and leucine-rich repeat protein 2/20. Ubiquitin system [BR: ko04121] Ubiquitin ligases (E3) Multi subunit Ring-finger type E3. SCF complex. Target recognizing subunit (F-box) K10268 FBXL2_20; F-box and leucine-rich repeat protein 2/20. BRITE hierarchy. briggs and stratton pressure washer pump