WebMar 11, 2024 · The GPI consists of the conserved core glycan, phosphatidylinositol and glycan side chains. The entire GPI-AP is anchored to the outer leaflet of the lipid bilayer … WebSep 1, 1999 · The discovery of glycosylphosphatidylinositol (GPI) membrane anchors has had a significant impact on several areas of eukaryote cell biology. Studies of the African trypanosome, which expresses a dense surface coat of GPI-anchored variant surface glycoprotein, have played important roles in establishing the general structure of GPI …
Multi-omic characterization of the maize GPI synthesis mutant
WebThe study of Kadmon et al suggested that mouse CD24 (ie, nectadrin) is a cell adhesion glycoprotein exhibiting homophilic binding. 34 It is possible that this type of interaction is carbohydrate-mediated and reflects the ability of GPI-anchored proteins to cluster in lipid rafts. 20 In mouse brain, CD24 can interact in a carbohydrate-dependent ... WebFeb 17, 1998 · PSCA Is a GPI-Anchored Glycoprotein Expressed on the Cell Surface. The deduced PSCA amino acid sequence predicts that PSCA is heavily glycosylated and anchored to the cell surface through a GPI mechanism. To test these predictions, we produced an affinity-purified polyclonal antibody raised against a unique PSCA peptide. laura hessen wjr
GPI-anchored proteins are organized in submicron domains at
WebThe M5E2 monoclonal antibody specifically binds to CD14, a 53–55 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein expressed at high levels on monocytes. Additionally, the anti-CD14 antibody reacts with interfollicular macrophages, reticular dendritic cells, and some Langerhans cells. WebDec 15, 2010 · CD109 is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein, whose expression is upregulated in squamous cell carcinomas of the lung, esophagus, uterus and oral cavity. CD109 negatively regulates transforming growth factor (TGF)-beta signaling in keratinocytes by directly modulating receptor … WebJul 24, 2024 · CD52, a glycophosphatidylinositol (GPI)-anchored glycoprotein, is released in a soluble form following T cell activation and binds to the Siglec (sialic acid-binding Ig-like lectin)-10 receptor on T cells to suppress their function. We show that binding of CD52-Fc to Siglec-10 and T cell suppression requires the damage-associated molecular ... laura heumann