Phosphatase tensin-type domain
Web132 rows · Apr 4, 2024 · Summary. This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains … WebPhosphatase and tensin homolog (PTEN) is a tumor suppressor and component of PI3K-AKT-mTOR signaling. Cowden syndrome is an inherited, autosomal dominant phenotype composed of multiple hamartomas typically found in the skin, mucous membranes including the gastrointestinal tract, thyroid, and breast.
Phosphatase tensin-type domain
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Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been … See more PTEN protein acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN specifically catalyses the dephosphorylation of the 3` phosphate of the See more The structure of the core of PTEN (solved by X-ray crystallography, see figure to the upper right ) reveals that it consists primarily of a phosphatase domain, and a C2 domain: the phosphatase domain contains the active site, which carries out the See more PTEN inhibitors Bisperoxovanadium compounds may have a neuroprotective effect after CNS injury. PTEN is inhibited by See more PTEN (gene) has been shown to interact with: • CSNK2A2, • CSNK2A1, • MAGI3 • MVP, • NEDD4, See more Cancer PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. A number of studies … See more Cell lines with known PTEN mutations include: • prostate: LNCaP, PC-3 • kidney: 786-O • glioblastoma: U87MG • breast : MB-MDA-468, BT549 See more • Multiple hamartoma syndrome See more WebJun 27, 2006 · The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK19A is characterized by onset of parkinsonian symptoms in the first or second decade of life.
WebGene Variant Descriptions. PTEN H93Q lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). H93Q demonstrates Pten protein stability similar to wild-type protein ( PMID: 32350270, PMID: 32366478 ), however, results in a partial loss of ability to rescue spheroid formation ( PMID: 32366478 ), fails to suppress Akt ... WebMar 21, 2024 · The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. ... interacts (via C2 tensin-type domain) with p85 but, following growth factor stimulation, PTEN is …
WebEnables lipid phosphatase activity. Acts upstream of or within several processes, including lifelong otolith mineralization; negative regulation of angiogenesis; and phosphatidylinositol dephosphorylation. Predicted to be located in PML body and cytoplasm. WebDescription: Homo sapiens transmembrane phosphatase with tensin homology (TPTE), transcript variant 1, mRNA. (from RefSeq NM_199261) RefSeq Summary (NM_199261): …
WebMar 21, 2024 · PTEN is a multi-functional tumor suppressor that is very commonly lost in human cancer. Observed in prostate cancer, glioblastoma, endometrial, lung and breast …
WebNov 4, 2024 · Also known as ATPEN2; phosphatase and TENsin homolog deleted on chromosome ten 2A; PTEN 2; PTEN2A Summary Encodes a phosphatase with low in vitro tyrosine phosphatase activity that is capable of dephosphorylating in vitro the 3'phosphate group of PI3P, PI (3,4)P2, and PI (3,5)P2 and may be an effector of lipid signaling. NEW … solva beach pembrokeshireWeb1 day ago · This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a … solva fireworks 2022WebChain A, Tensin-like C1 domain-containing phosphatase (human) Protein Target - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW … solv accountWebAug 26, 2024 · The importance of phosphatase and tensin homolog deleted on chromosome ten ( PTEN) in tumorigenesis is underscored by its frequent mutations, including missense, nonsense, frameshift, and large... solvafond speciesWebBreast cancer has been attributed to be the second most common malignancy in females worldwide after skin cancer associated with a significantly high mortality rate. Tumor suppressor genes have an indispensable role in maintaining genomic integrity small bottles of malibuWebApr 3, 2024 · PTEN phosphatase and tensin homolog Gene ID: 5728, updated on 3-Apr-2024 Gene type: protein coding Also known as: BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; … small bottles of men\u0027s cologneWebJan 2, 2024 · Phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) encodes a 403-amino acid protein with an amino-terminal domain that shares sequence … solva cottages pembrokeshire