WebPSMB9 knockdown and the use of i-proteasome-specific inhibitors both decreased 26S proteasome activities and prevented C2C12 differentiation. Inhibition of the i-proteasome also impaired human skeletal myoblast differentiation. WebAug 1, 2024 · We present the case of a patient with a novel type I interferonopathy caused by a de novo PSMB9 p.G156D mutation that suppressed the wild-type PSMB9 protein expression. Janus kinase inhibitor and stem cell transplantation could be curative therapies in patients with severe interferonopathies.

National Center for Biotechnology Information

WebFeb 6, 2024 · For example, high PSMB8 and PSMB9 expression correlates with better outcomes and response to immune checkpoint inhibitors for melanoma patients 27 and … WebPSMB8, PSMB9, and PSMB10 form a complex that activates the immune response. Recent studies have shown that the PSMB8 immunoproteasome can degrade NF-κB production inhibition of NF-κB production by NF-κB inhibitors, 40 which are a key step in inflammation regulation. In contrast, PSMB8 can activate NF-κB through the action of the ... jonathan choe komo twitter

Immunoproteasome deficiency is a feature of non-small cell lung ... - PNAS

WebKawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide … WebAnalysis of a dataset (GSE2109) containing metastatic and primary lung adenocarcinomas revealed a significantly reduced expression of PSMB8 ( P = 0.001), PSMB9 ( P < 0.002), HLA-A ( P = 0.042), HLA-B ( P = 0.017), and HLA-C ( P = 0.007) in metastatic compared with primary tumors ( SI Appendix, Fig. S3 E and F ). how to index on bing