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WebFeb 2, 2024 · THIO is investigational and has not been approved for any use by regulatory authorities. About MAIA Biotechnology, Inc. MAIA Biotechnology, Inc. is a targeted therapy, immuno-oncology company ... WebFirst-in-class cancer telomere targeting agent. THIO (aka 6-thio-dG, 6-thio-2’-deoxyguanosine) is a potentially first-in-class small molecule that is the only direct telomere targeting agent currently in clinical development. Telomerase is present in >85% of human cancers and contributes significantly to the proliferation and reproductive ... WebAug 22, 2015 · Recently, we reported that a telomerase-mediated telomere-disrupting compound, 6-thio-2'-deoxyguanosine (6-thio-dG), was very effective at targeting telomerase positive cancer cells while sparing telomerase silent normal cells. 6-thio-dG, a nucleoside analogue of the already-approved drug 6-thioguanine, is incorporated into telomeres by ... red howell fort wayne